BCAR-Sponsored Research

Cross-generational Epigenetic Effects of Pre-Conception Alcohol Use on Gene Expression Associated with Cancer Susceptibility
Principal Investigator(s): Shirley Y. Hill, PhD and Gregg Homanics, PhD
Co-Investigator(s): Sean P. Farris, PhD

Publications and Presentations:
(1) SY Hill, GE Homanics, SF Farris. Transcriptome differences in lymphocytes between youth with parents with alcohol use disorder (AUD) versus those with parents and grandparents with AUD and controls: The role of cross-generational effects. 

(2) SF Farris, RC Rice, SY Hill, GE Homanics. Cross-generational effects of chronic ethanol exposure on the transcriptome in C57BL/6J mice.

(3) SY Hill, GE Homanics, RC Rice, SF Farris. Intergenerational effects of chronic ethanol  exposure on the transcriptome: Human and animal findings.

(4) RC Rice, GE Homanics, SY Hill, SF Farris. Intergenerational effects of chronic ethanol  exposure on the noncoding transcriptome. Translational Neuroscience of Alcohol: Integration of Basic and Clinical Research, Gordon Conference, February 11-16, 2024

Identification of Novel Treatments for Alcohol Use Disorder with Comorbid Chronic Pain
Principal Investigator(s): Sean P. Farris, PhD and Bradley K. Taylor, PhD
Co-Investigator(s): Mary M. Torregrossa, PhD; David A. Lewis, MD; Jill R. Glausier, PhD

Publications and Presentations:
(1) Brandner, A. J., Baratta, A. M., Rathod, R. S., Ferguson, C., Taylor, B. K., & Farris, S. P. (2023). Mechanical and Heat Hyperalgesia upon Withdrawal From Chronic Intermittent Ethanol Vapor Depends on Sex, Exposure Duration, and Blood Alcohol Concentration in Mice. The journal of pain, 24(7), 1262–1274. https://doi.org/10.1016/j.jpain.2023.02.024

Pharmacokinetic profiling of Δ9-THC metabolism and association with levels of cognitive impairment and modulation by stress
Principal Investigator(s): Mary M. Torregrossa, PhD; Aaron Devanathan, PharmD, PhD, AAHIVP; Sarah Pedersen, PhD

Project work begins in Spring 2024.